| Identification | More | [Name]
(R)-3-Amino-1-benzylpiperidine | [CAS]
168466-84-0 | [Synonyms]
1-BENZYL-PIPERIDIN-(R)-3-YLAMINE
(R)-1-BENZYL-3-AMINOPIPERIDINE
(R)-1-BENZYL-PIPERIDIN-3-YLAMINE
(R)-3-AMINO-1-BENZYL-PIPERIDINE
(r)-n-benzyl-3-amino-piperidine
(R)-1-benzylpiperidin-3-amine | [Molecular Formula]
C12H18N2 | [MDL Number]
MFCD03093374 | [Molecular Weight]
190.28 | [MOL File]
168466-84-0.mol |
| Hazard Information | Back Directory | [Chemical Properties]
White powder or yellow liquid | [Uses]
(R)-3-Amino-1-benzylpiperidine is used as an organic chemical synthesis intermediate. | [Synthesis]
Example 33: Preparation of (R)-1-benzyl-3-aminopiperidine
(R)-1-benzylpiperidinamide (1.1 g) described in Example 2 was used as a starting material, which was mixed with water (5 mL), 30% aqueous sodium hydroxide (6.7 g, 10 eq.), tetrahydrofuran (THF, 10 mL), and an aqueous sodium hypochlorite solution (11.2 g, 1.5 eq.). The reaction mixture was stirred at 15°C for 1 hour, then warmed to 60°C and continued stirring for 2 hours. Upon completion of the reaction, the mixture was cooled to 20 °C and extracted three times with toluene (10 mL). After combining the organic layers, the solvent was removed by concentration under reduced pressure to afford the target product (R)-3-amino-1-benzylpiperidine as a yellow-brown oil (0.8 g, yield: 55%). | [References]
[1] Patent: US2010/105917, 2010, A1. Location in patent: Page/Page column 21 |
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