| Identification | Back Directory | [Name]
1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)-, hydrochloride (1:1) | [CAS]
1691221-67-6 | [Synonyms]
1H-Imidazo[4,5-f][1,10]phenanthroline, 2-(5-fluoro-2-methyl-1H-indol-3-yl)-, hydrochloride (1:1) | [Molecular Formula]
C22H15ClFN5 | [MOL File]
1691221-67-6.mol | [Molecular Weight]
403.85 |
| Hazard Information | Back Directory | [Uses]
APTO-253?(LOR-253) hydrochloride is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253?hydrochloride mediates anticancer activity via induction of Kruppel-like factor 4?(KLF4)?tumor suppressor. APTO-253?hydrochloride exhibits antiarthritic activity[1]. | [References]
[1] Local A, et al. APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells. Mol Cancer Ther. 2018 Jun;17(6):1177-1186. [Content Brief] DOI:10.1158/1535-7163.MCT-17-1209
[2] Hongying Zhang, et al. Inhibition of c-Myc By Apto-253 As an Innovative Therapeutic Approach to Induce Cell Cycle Arrest and Apoptosis in Acute Myeloid Leukemia. Blood 2016 128:1716.
[3] Haruka Tsuchiya, et al. Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis. Ann Rheum Dis. 2020 Nov2;annrheumdis-2020-218189. DOI:10.1136/annrheumdis-2020-218189 |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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