| Identification | Back Directory | [Name]
tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate | [CAS]
1698027-20-1 | [Synonyms]
1588-A4
ARS-1620 Intermediate
tert-butyl 4-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylate
1-Piperazinecarboxylic acid, 4-(7-bromo-6-chloro-8-fluoro-4-quinazolinyl)-, 1,1-dimethylethyl ester | [Molecular Formula]
C17H19BrClFN4O2 | [MOL File]
1698027-20-1.mol | [Molecular Weight]
445.71 |
| Chemical Properties | Back Directory | [Boiling point ]
534.9±50.0 °C(Predicted) | [density ]
1.521±0.06 g/cm3(Predicted) | [solubility ]
DMSO: Slightly soluble: 0.1-1 mg/ml | [pka]
10.06±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
1588-A4 is a synthetic intermediate that has been used in the synthesis of the K-RasG12C inhibitor ARS1620 (Item No. 27915).1 WARNING This product is not for human or veterinary use. | [References]
[1] MATTHEW R JANES. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.[J]. Cell, 2018, 172 3: 578-589.e17. DOI: 10.1016/j.cell.2018.01.006 |
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