| Identification | Back Directory | [Name]
4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid | [CAS]
170355-78-9 | [Synonyms]
CD 2665
4-[7-(1-ADAMANTYL)-6-(2-METHOXYETHOXYMETHOXY)NAPHTHALEN-3-YL]BENZOIC ACID
4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid
4-[6-[(2-Methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoicacid
Benzoic acid, 4-[6-[(2-methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl]- | [Molecular Formula]
C31H34O5 | [MDL Number]
MFCD13176719 | [MOL File]
170355-78-9.mol | [Molecular Weight]
486.6 |
| Chemical Properties | Back Directory | [Boiling point ]
668.6±55.0 °C(Predicted) | [density ]
1.227±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 25 mg/ml | [form ]
A crystalline solid | [pka]
4.13±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CD 2665 is a selective RARβ/γ antagonist. | [Biological Activity]
Selective RAR β / γ antagonist (K D values are 110, 306 and > 1000 nM for RAR γ , RAR β and RAR α respectively). Blocks retinoic acid-induced apoptosis ex vivo . | [in vivo]
CD2665 (0.6 mg/kg; Subcutaneous injection; daily, for 22 days) completely inhibits the overexpression of RARβ mRNA in the brain of alcohol treated mice[2].
CD2665 is a selective retinoid antagonist and elicits the expected maturation delay and growth plate expansion[3]. | Animal Model: | Mice submitted to 10 months of ethanol consumption[2]. | | Dosage: | 0.6 mg/kg | | Administration: | Subcutaneous injection; daily, for 22 days. | | Result: | Decreased brain RARβ mRNA levels (50% relative to control), without any change in RXR β/γ mRNA levels.
|
| Animal Model: | Male and female mice (3 weeks)[3]. | | Dosage: | 1.6 mg/kg | | Administration: | Oral gavage/intragastric; daily, for 31 days. | | Result: | Growth plate closure had largely been prevented in LDE225/antagonist co-treated mice compared with those receiving LDE225 only. |
| [storage]
Store at +4°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|