| Identification | Back Directory | [Name]
Acetic acid, 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]-, hexadecyl ester | [CAS]
1706528-83-7 | [Synonyms]
INS-1009
Treprostinil palmitil
Acetic acid, 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]-, hexadecyl ester | [Molecular Formula]
C39H66O5 | [MOL File]
1706528-83-7.mol | [Molecular Weight]
614.94 |
| Chemical Properties | Back Directory | [Boiling point ]
705.7±60.0 °C(Predicted) | [density ]
1.007±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [solubility ]
DMSO : 200 mg/mL (325.23 mM; Need ultrasonic) | [form ]
Solid | [pka]
15.09±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Treprostinil palmitil (TP) is the proagent of DP1 and EP2 agonist, Treprostinil (UT-15), whose EC50 values were 0.6 and 6.2 nM, respectively. Treprostinil palmitil is a pure proagent and possesses no inherent binding to G-protein coupled receptors including prostanoid receptors[1][2]. | [IC 50]
DP | [storage]
4°C, away from moisture and light | [References]
[1] Chapman RW, Corboz MR, Malinin VS, Plaunt AJ, Konicek DM, Li Z, Perkins WR. An overview of the biology of a long-acting inhaled treprostinil prodrug. Pulm Pharmacol Ther. 2020 Dec;65:102002. DOI:10.1016/j.pupt.2021.102002 |
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