| Identification | Back Directory | [Name]
(RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID | [CAS]
170847-18-4 | [Synonyms]
rac-APICA
(RS)-APICA
(RS) APICA,(RS)APICA
(RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID
1H-Indene-1-carboxylic acid, 1-amino-2,3-dihydro-5-phosphono- | [Molecular Formula]
C10H12NO5P | [MDL Number]
MFCD01321070 | [MOL File]
170847-18-4.mol | [Molecular Weight]
257.18 |
| Chemical Properties | Back Directory | [Boiling point ]
559.9±60.0 °C(Predicted) | [density ]
1?+-.0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at +4°C | [solubility ]
Soluble to 100 mM in 1.1eq. NaOH | [form ]
Powder | [pka]
1.34±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(RS)-APICA is a group II metabotropic glutamate receptor antagonist. | [Biological Activity]
The rigidified analog of MPPG ((RS)-a-Methyl-4-phosphonophenylglycine ); a selective group II metabotropic glutamate receptor antagonist (IC 50 = 30 μ M) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses an unusual inverse agonist-like action. | [IC 50]
mGluR2 | [storage]
Store at -20°C |
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| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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