| Identification | Back Directory | [Name]
1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-2-oxo-N-[[4-(1,2,4,5-tetrazin-3-yl)phenyl]methyl]-, (3aS,4S,6aR)- | [CAS]
1714123-51-9 | [Synonyms]
Tetrazine-biotin
1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-2-oxo-N-[[4-(1,2,4,5-tetrazin-3-yl)phenyl]methyl]-, (3aS,4S,6aR)- | [Molecular Formula]
C19H23N7O2S | [MDL Number]
MFCD28579826 | [MOL File]
1714123-51-9.mol | [Molecular Weight]
413.5 |
| Hazard Information | Back Directory | [Uses]
Tetrazine-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Tetrazine-biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. | [IC 50]
Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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