| Identification | Back Directory | [Name]
N2-iso-Butyroyl-5'-(4,4'-dimethoxytrityl)-2'-O-propargylguanosine | [CAS]
171486-53-6 | [Synonyms]
5’-O-DMT-N2-isobutyryl-2’-O-propargylguanosine
5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine
5'-O-DMT-2'-O-propargyl-N2-isobutyryl-guanosine
N2-iso-Butyroyl-5'-(4,4'-dimethoxytrityl)-2'-O-propargylguanosine
N2-iso-Butyroyl-5’-O-(4,4’-dimethoxytrityl)-2’-O-propargylguanosine
Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-2'-O-2-propyn-1-yl- | [Molecular Formula]
C38H39N5O8 | [MDL Number]
MFCD28976149 | [MOL File]
171486-53-6.mol | [Molecular Weight]
693.745 |
| Hazard Information | Back Directory | [Uses]
5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. | [References]
[1] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100 |
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