| Identification | Back Directory | [Name]
Nitidanin | [CAS]
171674-89-8 | [Synonyms]
Nitidanin
(2R,3R)-rel-2,3-Dihydro-3-(4-hydroxy-3,5-dimethoxyphenyl)-6-[(1E)-3-hydroxy-1-propen-1-yl]-8-methoxy-1,4-benzodioxin-2-methanol
1,4-Benzodioxin-2-methanol, 2,3-dihydro-3-(4-hydroxy-3,5-dimethoxyphenyl)-6-[(1E)-3-hydroxy-1-propen-1-yl]-8-methoxy-, (2R,3R)-rel- | [Molecular Formula]
C21H24O8 | [MOL File]
171674-89-8.mol | [Molecular Weight]
404.41 |
| Hazard Information | Back Directory | [Uses]
Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C. Nitidanin is shows IC50 values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum, respectively. Nitidanin can be used for the research of malaria and virus infection[1][2]. | [IC 50]
Plasmodium | [References]
[1] Ma C, et al. Antimalarial compounds from Grewia bilamellata. J Nat Prod. 2006 Mar;69(3):346-50. DOI:10.1021/np050313d
[2] Pilkington LI, et al. 1,4-Benzodioxane Lignans: An Efficient, Asymmetric Synthesis of Flavonolignans and Study of Neolignan Cytotoxicity and Antiviral Profiles. J Nat Prod. 2018 Dec 28;81(12):2630-2637. DOI:10.1021/acs.jnatprod.8b00416 |
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