| Identification | Back Directory | [Name]
NATRIUM[(1-BENZYL-2-ETHYL-3-OXAMOYLINDOOL-4-YL)OXY]ACETAAT | [CAS]
172733-42-5 | [Synonyms]
LY 315920Na
LY 315920 sodium
Varespladib sodium
LY315920 sodiuM salt
NATRIUM[(1-BENZYL-2-ETHYL-3-OXAMOYLINDOOL-4-YL)OXY]ACETAAT
[[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid monosodium salt | [Molecular Formula]
C21H19N2NaO5 | [MOL File]
172733-42-5.mol | [Molecular Weight]
402.376 |
| Hazard Information | Back Directory | [Uses]
Treatment of sepsis (sPLA2inhibitor). | [in vivo]
Varespladib sodium treatment inhibits human sPLA2-induced release of thromboxane A2 (TXA2) from isolated guinea pig lung bronchoalveolar lavage cells with an IC50 of 0.79 μM. And the ED50 for Varespladib sodium is 16.1 mg/kg[1].
| Animal Model: | Male Hartley guinea pigs (300-500 g)[1] | | Dosage: | 3 mg/kg, 10 mg/kg, and 30 mg/kg | | Administration: | Intravenous injection (Pharmacokinetic study) | | Result: | Consistent inhibition of sPLA2 activity in BAL fluid was observed. Reduced the human sPLA2-induced generation of TXA2 on BAL cells from guinea pigs. |
| [IC 50]
sPLA2: 9 nM (IC50) |
|
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NCE Biomedical Co.,Ltd.
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| Company Name: |
MedChemExpress
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www.medchemexpress.com |
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