| Identification | More | [Name]
3-BROMO-2-HYDROXY-5-METHYLPYRIDINE | [CAS]
17282-02-9 | [Synonyms]
3-BROMO-2-HYDROXY-5-METHYLPYRIDINE
3-BROMO-5-METHYL-2(1H)-PYRIDINONE
3-BROMO-5-METHYLPYRIDIN-2-OL
TIMTEC-BB SBB003679
2-HYDROXY-3-BROMO-5-PICOLINE
3-Bromo-2-hydroxy-5-picoline
3-Bromo-2-hydroxy-5-methylpyridine 98%
3-Bromo-2-hydroxy-5-picoline 17282-02-9
3-BROMO-2-HYDROXY-5-PICOLINE (3-BROMO-2-HYDROXY-5-METHYLPYRIDINE)
3-Bromo-5-methyl-2-pyridone | [EINECS(EC#)]
623-885-0 | [Molecular Formula]
C6H6BrNO | [MDL Number]
MFCD03791312 | [Molecular Weight]
188.02 | [MOL File]
17282-02-9.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing . | [RIDADR ]
1993 | [WGK Germany ]
3
| [Hazard Note ]
Irritant/Keep Cold | [PackingGroup ]
III | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Synthesis]
5-Methylpyridin-2-ol (1 g, 9.16 mmol) was used as starting material and dissolved in 4 mL of carbon disulfide (CS2). Bromine (Br2, 0.47 mL) was slowly added to this solution at room temperature and the reaction mixture was stirred for 2 hours. Upon completion of the reaction, aqueous sodium thiosulfate (Na2S2O3) was added to quench the reaction, followed by extraction of the reaction mixture with ethyl acetate (EtOAc). The organic layer was separated, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to afford the solid product 3-bromo-2-hydroxy-5-methylpyridine (1.7 g, 98% yield). The structure of the product was confirmed by 1H-NMR (CDCl3): δ 7.73 (1H, s), 7.22 (1H, s), 2.10 (3H, s). | [References]
[1] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0168
[2] Patent: US2008/85906, 2008, A1. Location in patent: Page/Page column 15 |
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