| Identification | Back Directory | [Name]
L-Alanine, N-[(2S)-3-(1,3-benzodioxol-5-yl)-2-(mercaptomethyl)-1-oxopropyl]-, phenylmethyl ester | [CAS]
173429-64-6 | [Synonyms]
BP1137
BP-1137
BP 1137
L-Alanine, N-[(2S)-3-(1,3-benzodioxol-5-yl)-2-(mercaptomethyl)-1-oxopropyl]-, phenylmethyl ester | [Molecular Formula]
C21H23NO5S | [MOL File]
173429-64-6.mol | [Molecular Weight]
401.48 |
| Hazard Information | Back Directory | [Description]
Aladotril inhibits neutral endopeptidase; prodrug of aladotrilat. | [Uses]
Aladotril (BP1137) is the inhibitor for neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE), that ameliorates the cardiac hypertrophy in rats, without decreasing the blood pressure. Aladotril can be used in research about heart failure and cardiac remodeling after myocardial infarction[1]. | [References]
[1] Marie C, et al., Effect of long-term therapy with fasidotril, a mixed inhibitor of neprilysin and angiotensin-converting enzyme (ACE), on survival of rats after myocardial infarction. Cardiovasc Res. 1999 Mar;41(3):544-53. DOI:10.1016/s0008-6363(98)00257-0 |
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