| Identification | Back Directory | [Name]
(+/-)-4-(4-AMINOPHENYL)-1,2-DIHYDRO-1-METHYL-2-PROPYLCARBAMOYL-6,7-METHYLENEDIOXYPHTHALAZINE | [CAS]
173952-44-8 | [Synonyms]
CS-2046
SYM 2206
SYM2206;SYM 2206;SYM-2206
8-(4-Aminophenyl)-5-methyl-N-propyl-1,3-dioxolo[4,5-g]phthalazine-6(5H)-carboxamide
1,3-Dioxolo[4,5-g]phthalazine-6(5H)-carboxamide, 8-(4-aminophenyl)-5-methyl-N-propyl-
(S)-8-(4-aminophenyl)-5-methyl-N-propyl-[1,3]dioxolo[4,5-g]phthalazine-6(5H)-carboxamide
(+/-)-4-(4-AMINOPHENYL)-1,2-DIHYDRO-1-METHYL-2-PROPYLCARBAMOYL-6,7-METHYLENEDIOXYPHTHALAZINE
SYM 2206,(±)-4-(4-Aminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylenedioxyphthalazine | [Molecular Formula]
C20H22N4O3 | [MDL Number]
MFCD00946571 | [MOL File]
173952-44-8.mol | [Molecular Weight]
366.41 |
| Chemical Properties | Back Directory | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO : 100 mg/mL (272.92 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) | [form ]
Powder | [pka]
15.26±0.60(Predicted) | [color ]
Light yellow to yellow | [CAS DataBase Reference]
173952-44-8 |
| Hazard Information | Back Directory | [Uses]
SYM 2206 is a potent, selective and noncompetitive AMPA receptor inhibitor. | [Definition]
ChEBI: 8-(4-aminophenyl)-5-methyl-N-propyl-5H-[1,3]dioxolo[4,5-g]phthalazine-6-carboxamide is a member of phthalazines. | [Biological Activity]
Novel, potent, non-competitive AMPA receptor antagonist (IC 50 = 2.8 μ M ). Acts allosterically at the same regulatory site as GYKI 52466 and 53655 and other benzodiazepines but does not bind to the central diazepine binding site. Selective for AMPA relative to kainate receptor sub-types. Similar potency to GYKI 53655. Anticonvulsant in vivo . | [storage]
Store at RT |
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