| Identification | Back Directory | [Name]
TAS 103 | [CAS]
174634-09-4 | [Synonyms]
CS-1342
TAS-103(2HCl)
BMS-247615-2HCl
TAS-103(BMS-247615)
TAS 103 (hydrochloride)
BMS247615 dihydrochloride
BMS-247615 dihydrochloride
BMS 247615 dihydrochloride
TAS-103 (dihydrochloride)
TAS 103 dihydrochloride, BMS 247615 dihydrochloride
6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride
TAS-103;TAS103; BMS 247615; BMS-247615; BMS-247615 DIHYDROCHLORIDE; TAS103 DIHYDROCHLORIDE; TAS 103 DIHYDROCHLORIDE; BMS247615 DIHYDROCHLORIDE; BMS 247615 DIHYDROCHLORIDE | [Molecular Formula]
C20H21Cl2N3O2 | [MDL Number]
MFCD00943251 | [MOL File]
174634-09-4.mol | [Molecular Weight]
406.306 |
| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
PBS (pH 7.2):1.0(Max Conc. mg/mL);2.46(Max Conc. mM) | [form ]
A crystalline solid | [color ]
Brown to orange |
| Hazard Information | Back Directory | [Uses]
TAS 103 is a novel anti-cancer agent developed to inhibit both toposiomerase (Topo) I and Topo II. | [in vivo]
TAS-103 (30 mg/kg, i.v.) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103[2]. | [IC 50]
Topoisomerase I; Topoisomerase II |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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