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174634-09-4

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174634-09-4 Structure

174634-09-4 Structure
IdentificationBack Directory
[Name]

TAS 103
[CAS]

174634-09-4
[Synonyms]

CS-1342
TAS-103(2HCl)
BMS-247615-2HCl
TAS-103(BMS-247615)
TAS 103 (hydrochloride)
BMS247615 dihydrochloride
BMS-247615 dihydrochloride
BMS 247615 dihydrochloride
TAS-103 (dihydrochloride)
TAS 103 dihydrochloride, BMS 247615 dihydrochloride
6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride
TAS-103;TAS103; BMS 247615; BMS-247615; BMS-247615 DIHYDROCHLORIDE; TAS103 DIHYDROCHLORIDE; TAS 103 DIHYDROCHLORIDE; BMS247615 DIHYDROCHLORIDE; BMS 247615 DIHYDROCHLORIDE
[Molecular Formula]

C20H21Cl2N3O2
[MDL Number]

MFCD00943251
[MOL File]

174634-09-4.mol
[Molecular Weight]

406.306
Chemical PropertiesBack Directory
[storage temp. ]

Inert atmosphere,2-8°C
[solubility ]

PBS (pH 7.2):1.0(Max Conc. mg/mL);2.46(Max Conc. mM)
[form ]

A crystalline solid
[color ]

Brown to orange
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

TAS 103 is a novel anti-cancer agent developed to inhibit both toposiomerase (Topo) I and Topo II.
[in vivo]

TAS-103 (30 mg/kg, i.v.) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103[2].

[IC 50]

Topoisomerase I; Topoisomerase II
Spectrum DetailBack Directory
[Spectrum Detail]

TAS 103(174634-09-4)1HNMR
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