174634-09-4

中文名称 6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐

英文名称 TAS 103

CAS 174634-09-4

分子式 C20H21Cl2N3O2

分子量 406.306

MOL 文件 174634-09-4.mol

更新日期 2024/06/17 17:25:40

174634-09-4 结构式

基本信息物理化学性质安全数据 6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐价格(试剂级) 常见问题列表

基本信息

中文别名

TAS-103双盐酸盐
TAS-103(BMS-247615)盐
拓扑异构酶I和II抑制剂(TAS-103双盐酸盐)
6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐

英文别名

CS-1342
TAS-103(2HCl)
BMS-247615-2HCl
TAS-103(BMS-247615)
TAS 103 (hydrochloride)
BMS247615 dihydrochloride
BMS-247615 dihydrochloride
BMS 247615 dihydrochloride
TAS-103 (dihydrochloride)
TAS 103 dihydrochloride, BMS 247615 dihydrochloride

所属类别

生物化工：激动剂抑制剂

物理化学性质

储存条件Inert atmosphere,2-8°C

溶解度PBS (pH 7.2):1.0(Max Conc. mg/mL);2.46(Max Conc. mM)

形态结晶固体

颜色Brown to orange

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS07

警示词警告

危险性描述H302-H315-H319-H335

防范说明P261-P305+P351+P338

6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/02/08	HY-13758A	6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐 TAS-103 dihydrochloride	174634-09-4	1 mg	500元
2025/02/08	HY-13758A	6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐 TAS-103 dihydrochloride	174634-09-4	5mg	1100元
2025/02/08	HY-13758A	6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐 TAS-103 dihydrochloride	174634-09-4	10mM * 1mLin Water	1210元

常见问题列表

生物活性

TAS-103 dihydrochloride 是一种 DNA 拓扑异构酶 I/II (topoisomerase I/II) 双重抑制剂，可用于癌症研究。

靶点

Topoisomerase I

Topoisomerase II

体外研究

TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC ₅₀ value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103. TAS-103 inhibits the viability of HeLa cells, with an IC ₅₀ of 40 nM. TAS-103 (10 μM) disrupts signal recognition particle (SRP) complex formation, and induces destabilization of SRP14 and SRP19 and its eventual degradation.

体内研究

TAS-103 (30 mg/kg, i.v.) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103.