| Identification | More | [Name]
5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE | [CAS]
175205-09-1 | [Synonyms]
KG-548
Activator 42
KG-548
(KG548)
BUTTPARK 1\01-72
Activator 42(R) 0.1 M
5-[3,5-Bis(trifluoromethyl)phenyl]-1H-tetra
5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE
5-[3,5-Bis(trifluoromethyl)phenyl]tetrazole97%
5-[3,5-Bis(trifluoromethyl)phenyl]-1H-tetrazole
5-[3,5-bis(trifluoromethyl)phenyl]-2H-tetrazole
5-[3,5-Bis(trifluoromethyl)phenyl]tetrazole 97%
2H-Tetrazole, 5-[3,5-bis(trifluoromethyl)phenyl]-
5-[3,5-Bis(trifluoromethyl)phenyl]-1H-tetrazole 97%
5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2H-1,2,3,4-TETRAAZOLE
5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2H-1,2,3,4-TETRAZOLE | [Molecular Formula]
C9H4F6N4 | [MDL Number]
MFCD00052524 | [Molecular Weight]
282.15 | [MOL File]
175205-09-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
177-180°C | [Boiling point ]
298.2±50.0 °C(Predicted) | [density ]
1.569±0.06 g/cm3(Predicted) | [Fp ]
5℃ | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [pka]
3.59±0.10(Predicted) | [color ]
white to beige | [InChI]
1S/C9H4F6N4/c10-8(11,12)5-1-4(7-16-18-19-17-7)2-6(3-5)9(13,14)15/h1-3H,(H,16,17,18,19) | [InChIKey]
KKJFZIQEWZVVIV-UHFFFAOYSA-N | [SMILES]
FC(F)(F)c1cc(cc(c1)c2n[nH]nn2)C(F)(F)F | [CAS DataBase Reference]
175205-09-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
25-36/37/38 | [Safety Statements ]
26-45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 2
Skin Irrit. 2 |
| Hazard Information | Back Directory | [Uses]
KG-548 is an ARNT/TACC3 disruptor and a HIF-1α inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as HIF-β[1][2]. | [References]
[1] Guo Y, et al. Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. ACS Chem Biol. 2013 Mar 15;8(3):626-35. DOI:10.1021/cb300604u
[2] Kleszcz R, et al. The inhibition of c-MYC transcription factor modulates the expression of glycolytic and glutaminolytic enzymes in FaDu hypopharyngeal carcinoma cells. Adv Clin Exp Med. 2018 Jun;27(6):735-742. DOI:10.17219/acem/68979 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|