| Identification | More | [Name]
5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE | [CAS]
175205-09-1 | [Synonyms]
KG-548
Activator 42
KG-548
(KG548)
BUTTPARK 1\01-72
Activator 42(R) 0.1 M
5-[3,5-Bis(trifluoromethyl)phenyl]-1H-tetra
5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE
5-[3,5-Bis(trifluoromethyl)phenyl]tetrazole97%
5-[3,5-Bis(trifluoromethyl)phenyl]-1H-tetrazole
5-[3,5-bis(trifluoromethyl)phenyl]-2H-tetrazole
5-[3,5-Bis(trifluoromethyl)phenyl]tetrazole 97%
2H-Tetrazole, 5-[3,5-bis(trifluoromethyl)phenyl]-
5-[3,5-Bis(trifluoromethyl)phenyl]-1H-tetrazole 97%
5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2H-1,2,3,4-TETRAAZOLE
5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2H-1,2,3,4-TETRAZOLE | [Molecular Formula]
C9H4F6N4 | [MDL Number]
MFCD00052524 | [Molecular Weight]
282.15 | [MOL File]
175205-09-1.mol |
| Hazard Information | Back Directory | [Uses]
KG-548 is an ARNT/TACC3 disruptor and a HIF-1α inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as HIF-β[1][2]. | [References]
[1] Guo Y, et al. Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. ACS Chem Biol. 2013 Mar 15;8(3):626-35. DOI:10.1021/cb300604u
[2] Kleszcz R, et al. The inhibition of c-MYC transcription factor modulates the expression of glycolytic and glutaminolytic enzymes in FaDu hypopharyngeal carcinoma cells. Adv Clin Exp Med. 2018 Jun;27(6):735-742. DOI:10.17219/acem/68979 |
|
|