| Identification | Back Directory | [Name]
1-PALMITOYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHATE(SODIUM SALT) | [CAS]
17618-08-5 | [Synonyms]
16:0 LPA
16:0 Lyso PA
PA(16:0/0:0)
16:0 LYSO PA SODIUM SALT
1-Palmitoyl Lysophosphatidic acid Sodium
1-Palmitoyl-lyso-Phosphatidic acid Na salt
Sodium (R)-2-hydroxy-3-(palmitoyloxy)propyl phosphate
1-PALMITOYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHATE(SODIUM SALT)
1-Palmitoyl Lysophosphatidic Acid (sodium salt) Exclusive
1-PALMITOYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHATE (SODIUM SALT);16:0 LYSO PA;16:0 LPA;PA(16:0/0:0) | [Molecular Formula]
C19H37Na2O7P | [MDL Number]
MFCD00674362 | [MOL File]
17618-08-5.mol | [Molecular Weight]
454.45 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: <.05 mg/ml; DMSO: <.05 mg/ml; Ethanol: <.05 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
1-Palmitoyl lysophosphatidic acid (1-Palmitoyl LPA) is a LPA analog containing palmitic acid at the sn-1 position. LPA binds to one of five different G protein-coupled receptors (GPCRs) to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility. In addition to playing a role in the aforementioned biological responses, 1-palmitoyl LPA enhances the action of β-lactam antibiotics (ampicillin, piperacillin, and ceftazidime) on various strains of Pseudomonas aeruginosa, a pathogen associated with pulmonary disease and pneumonia, via binding both Ca2+ and Mg2+. | [Uses]
(2R)-2-Hydroxy-3-(phosphonooxy)propyl hexadecanoate Sodium Salt is used in the test kit for screening colorectal adenoma. | [storage]
Store at -20°C | [References]
[1] KYOKO NOGUCHI Takao S Satoshi Ishii. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.[J]. The Journal of Biological Chemistry, 2003, 278 28: 25600-25606. DOI: 10.1074/jbc.m302648200
[2] MOOLENAAR W H. LPA: a novel lipid mediator with diverse biological actions.[J]. Trends in Cell Biology, 1994, 4 6: 213-219. DOI: 10.1016/0962-8924(94)90144-9
[3] K A KROGFELT. Specific phospholipids enhance the activity of beta-lactam antibiotics against Pseudomonas aeruginosa.[J]. Journal of Antimicrobial Chemotherapy, 2000, 46 3: 377-384. DOI: 10.1093/jac/46.3.377 |
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