| Identification | Back Directory | [Name]
Carbamic acid, N-[2-(2-azidoethoxy)ethyl]-, 1,1-dimethylethyl ester | [CAS]
176220-30-7 | [Synonyms]
Boc-NHCH2CH2-PEG1-azide
N-Boc-2-(2-azidoethoxy)ethanamine
tert-butyl (2-(2-azidoethoxy)ethyl)carbamate
tert-butyl N-[2-(2-azidoethoxy)ethyl]carbamate
Carbamic acid, N-[2-(2-azidoethoxy)ethyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C9H18N4O3 | [MDL Number]
MFCD29913352 | [MOL File]
176220-30-7.mol | [Molecular Weight]
230.264 |
| Hazard Information | Back Directory | [Uses]
Boc-NHCH2CH2-PEG1-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NHCH2CH2-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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