| Identification | Back Directory | [Name]
Bromo-PEG1-azide | [CAS]
1144106-65-9 | [Synonyms]
Bromo-PEG1-azide
Bromo-PEG1-C2-azide
Bromo-PEG1-azide, Bromo-PEG1-N3
1-azido-2-(2-bromoethoxy)ethane
1-Azido-2-(2-bromoethoxy)ethane/Bromo-PEG1-C2-azide | [Molecular Formula]
C4H8BrN3O | [MDL Number]
MFCD24454187 | [MOL File]
1144106-65-9.mol | [Molecular Weight]
194.03 |
| Hazard Information | Back Directory | [Description]
Bromo-PEG1-azide is a bifunctional PEG linker with a bromide (Br)group and an azide(N3) group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The bromide (Br) is a good leaving group for nucleophilic substitution reactions. | [Uses]
Bromo-PEG1-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromo-PEG1-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|