| Identification | Back Directory | [Name]
Pyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(1H)-one, 7-[2-[4-bromo-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-5,6,7,8-tetrahydro-2-phenyl- | [CAS]
1775330-54-5 | [Synonyms]
Pyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(1H)-one, 7-[2-[4-bromo-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-5,6,7,8-tetrahydro-2-phenyl- | [Molecular Formula]
C22H18BrF3N6O2 | [MOL File]
1775330-54-5.mol | [Molecular Weight]
535.32 |
| Chemical Properties | Back Directory | [Boiling point ]
668.5±65.0 °C(Predicted) | [density ]
1.72±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
8.05±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
PAT1inh-B01 is a selective SLC26A6 inhibitor. PAT1inh-B01 inhibits PAT1 (a Cl-/HCO3- exchanger)-mediated anion exchange (IC50: 350 nM). PAT1inh-B01 blocks fluid absorption in small intestine. PAT1inh-B01 can be used for research of small intestinal hyposecretory disorders[1]. | [References]
[1] Cil O, et al. SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine. JCI Insight. 2021 Jun 8;6(11):e147699. DOI:10.1172/jci.insight.147699 |
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