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1777832-90-2

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1777832-90-2 Structure

1777832-90-2 Structure
IdentificationBack Directory
[Name]

1777832-90-2
[CAS]

1777832-90-2
[Synonyms]

BAL3833
TBAP-001
BAL3833(TBAP-001)
pancreatic,TBAP-001,lung,Raf kinases,melanoma,Raf,inhibit,TBAP001,TBAP 001,carcinoma,Inhibitor,colorectal
1-(3-(tert-butyl)-1-(3-fluorophenyl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea
Urea, N-[4-[(3,4-dihydro-3-oxopyrido[2,3-b]pyrazin-8-yl)oxy]-2-fluorophenyl]-N'-[3-(1,1-dimethylethyl)-1-(3-fluorophenyl)-1H-pyrazol-5-yl]-
[Molecular Formula]

C27H23F2N7O3
[MDL Number]

MFCD32857166
[MOL File]

1777832-90-2.mol
[Molecular Weight]

531.51
Chemical PropertiesBack Directory
[density ]

1.42±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

8.41±0.20(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

TBAP-001 (Synthesis 13), extracted from patent WO2015075483A1, is a pan-RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay[1].
[References]

[1] Caroline Joy, et al. 1 -(5-TERT-BUTYL-2-ARYL-PYRAZOL-3-YL)-3-[2-FLUORO-4-[(3-OXO-4H-PYRIDO[2,
Spectrum DetailBack Directory
[Spectrum Detail]

1777832-90-2(1777832-90-2)1HNMR
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