| Identification | Back Directory | [Name]
β-catenin-IN-37 | [CAS]
1783856-40-5 | [Synonyms]
β-catenin-IN-37
β-catenin-IN-37
5H-[1,2,5]Oxadiazolo[3',4':5,6]pyrazino[2,3-b]indole, 5-[2-(2H-tetrazol-5-yl)ethyl]- | [Molecular Formula]
C13H9N9O | [MDL Number]
MFCD34567208 | [MOL File]
1783856-40-5.mol | [Molecular Weight]
307.27 |
| Chemical Properties | Back Directory | [Boiling point ]
563.2±60.0 °C(Predicted) | [density ]
1.99±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.33±0.10(Predicted) | [color ]
Orange to red |
| Hazard Information | Back Directory | [Uses]
β-catenin-IN-37 is a selective β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) inhibitor. β-catenin-IN-37 inhibits canonical Wnt signaling and the growth of colorectal cancer cells SW480 and HCT116 with the IC50 values of 20 μM and 31 μM, respectively[1]. | [References]
[1] Catrow JL, et al. Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J Med Chem. 2015;58(11):4678-4692. DOI:10.1021/acs.jmedchem.5b00223 |
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