| Identification | Back Directory | [Name]
2,4,6-Octatrienoicacid, 7-[3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-, (2E,4E,6E)- | [CAS]
178600-20-9 | [Synonyms]
LG1550
LG-1550
LGD-1550
ALRT-550
ALRT1550
ALRT-1550
ALRT 1550
2,4,6-Octatrienoicacid, 7-[3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-, (2E,4E,6E)- | [Molecular Formula]
C23H32O2 | [MOL File]
178600-20-9.mol | [Molecular Weight]
340.499 |
| Hazard Information | Back Directory | [Uses]
ALRT1550 (LGD1550) is a selective retinoic acid receptor (RAR) agonist that binds RARs with exceptional potency, with Kd values of approximately 1-4 nM. ALRT1550 exhibits anti-proliferative activity, with an IC50 value of 0.22 nM in UMSCC-22B squamous carcinoma cells. In a mouse tumor xenograft model, ALRT1550 inhibited tumor growth in a dose-dependent manner, achieving a maximum inhibition rate of 89%. ALRT1550 is applicable for research in the field of cancer[1][2]. | [References]
[1] Shalinsky DR, et al. A novel retinoic acid receptor-selective retinoid, ALRT1550, has potent antitumor activity against human oral squamous carcinoma xenografts in nude mice. Cancer Res. 1997 Jan 1;57(1):162-8. PMID:8988059
[2] Zhang L, et al. Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells. J Med Chem. 1996 Jul 5;39(14):2659-63. DOI:10.1021/jm960285j |
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