| Identification | Back Directory | [Name]
SDZ 220-581 (hydrochloride) | [CAS]
179411-93-9 | [Synonyms]
SDZ 220-581 (hydrochloride)
SDZ 220-581 hydrochloride >=98% (HPLC)
(S)-α-Amino-2-chloro-5-(phosphonomethyl)[1,1-biphenyl]-3-propanoic acid hydrochloride
(S)-alpha-Amino-2'-chloro-5-(phosphonomethyl)-[1,1'-biphenyl]-3-propanoic acid hydrochloride | [Molecular Formula]
C16H18Cl2NO5P | [MDL Number]
MFCD28124389 | [MOL File]
179411-93-9.mol | [Molecular Weight]
406.198 |
| Chemical Properties | Back Directory | [storage temp. ]
room temp | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [color ]
white to beige | [Optical Rotation]
[α]/D -5 to -8°, c = 1 in 1 M HCl |
| Hazard Information | Back Directory | [Uses]
SDZ 220-581 hydrochloride is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7[1]. | [Biological Activity]
sdz 220-581 hydrochloride is a potent and competitive antagonist of nmda receptor with pki value of 7.7 [1].sdz 220-581 is a biphenyl-ap7-derivative. it is potent both in vitro and in vivo. sdz 220-581 binds with high affinity to the recognition site of nmda receptor. it does not bind to the strychnine-insensitive glycine site or the mk-801 site within the nmda receptor. in addition, sdz 220-581 shows no effect on a variety of other binding assays such as for dopamine, serotonin and adenosine [1].in the in vivo assay, the administration of sdz 220-581 protects the mice against the maximal electroshock-induced seizures (mes). in the rat mes model, sdz 220-581 also shows potent efficacy. moreover, sdz 220-581 can protect brain against quinolinic acid induced neuronal degeneration in rat. furthermore, a dose of 1.25mg/kg sdz 220-581 markedly reduces the cerebral infarct size in the focal cerebral ischemia model in rat [2]. | [in vivo]
SDZ 220-581 (3.2-32 mg/kg; oral administration; for 24 hours; male OF-l mice) treatment dose-dependently protects mice against maximal electroshock seizures (MES). The time-course of protection by SDZ 220-581 is characterized by a rapid onset and long duration of action[1]. | Animal Model: | Male OF-l mice (18-26 g)[1] | | Dosage: | 3.2 mg/kg, 10 mg/kg, 32 mg/kg | | Administration: | Oral administration; for 24 hours | | Result: | Dose-dependently protected mice against maximal electroshock seizures (MES) upon oral administration.
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| [storage]
Store at -20°C | [References]
[1] urwyler et al .biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive n-methyl-d-aspartate receptor antagonists - ii. pharmacological characterization in vivo. neuropharmacology 1996, 35 655.
[2] urwyler s, campbell e, fricker g, et al. biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitiven-methyl-d-aspartate receptor antagonists—ii. pharmacological characterization in vivo[j]. neuropharmacology, 1996, 35(6): 655-669. |
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SPIRO PHARMA
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www.spiropharma.com.cn |
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Musechem
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+1-800-259-7612 |
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www.musechem.com |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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