179411-93-9
中文名称
(S)-ALPHA-氨基-2'-氯-5-(膦酰甲基)-[1,1'-联苯]-3-丙酸盐酸盐
英文名称
SDZ 220-581 (hydrochloride)
CAS
179411-93-9
分子式
C16H18Cl2NO5P
分子量
406.198
MOL 文件
179411-93-9.mol
179411-93-9 结构式
基本信息
中文别名
(S)-ALPHA-氨基-2'-氯-5-(膦酰甲基)-[1,1'-联苯]-3-丙酸盐酸盐 英文别名
SDZ 220-581 (hydrochloride)SDZ 220-581 hydrochloride >=98% (HPLC)
(S)-α-Amino-2-chloro-5-(phosphonomethyl)[1,1-biphenyl]-3-propanoic acid hydrochloride
(S)-alpha-Amino-2'-chloro-5-(phosphonomethyl)-[1,1'-biphenyl]-3-propanoic acid hydrochloride
所属类别
生物化工：激动剂抑制剂物理化学性质
储存条件room temp
溶解度DMSO：可溶5mg/mL，澄清（加热）
形态粉末
颜色白色至米色
旋光度 (Optical Rotation)[α]/D -5 to -8°, c = 1 in 1 M HCl
(S)-ALPHA-氨基-2'-氯-5-(膦酰甲基)-[1,1'-联苯]-3-丙酸盐酸盐价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-13059B | (S)-ALPHA-氨基-2'-氯-5-(膦酰甲基)-[1,1'-联苯]-3-丙酸盐酸盐 SDZ 220-581 hydrochloride | 179411-93-9 | 5 mg | 871元 |
| 2025/05/22 | HY-13059B | (S)-ALPHA-氨基-2'-氯-5-(膦酰甲基)-[1,1'-联苯]-3-丙酸盐酸盐 SDZ 220-581 hydrochloride | 179411-93-9 | 10mg | 1395元 |
| 2025/05/22 | HY-13059B | (S)-ALPHA-氨基-2'-氯-5-(膦酰甲基)-[1,1'-联苯]-3-丙酸盐酸盐 SDZ 220-581 hydrochloride | 179411-93-9 | 10mM * 1mLin DMSO | 1535元 |
常见问题列表
生物活性
SDZ 220-581 hydrochloride 是一种口服生物利用度，有效的竞争性的 NMDA 受体拮抗剂，pKi 值为 7.7。靶点
pKi: 7.7 ( NMDA receptor )
体内研究
SDZ 220-581 (3.2-32 mg/kg; oral administration; for 24 hours; male OF-l mice) treatment dose-dependently protects mice against maximal electroshock seizures (MES). The time-course of protection by SDZ 220-581 is characterized by a rapid onset and long duration of action.
| Animal Model: | Male OF-l mice (18-26 g) |
| Dosage: | 3.2 mg/kg, 10 mg/kg, 32 mg/kg |
| Administration: | Oral administration; for 24 hours |
| Result: | Dose-dependently protected mice against maximal electroshock seizures (MES) upon oral administration. |