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1799330-91-8

1799330-91-8 Structure

1799330-91-8 Structure
IdentificationBack Directory
[Name]

LFS-1107
[CAS]

1799330-91-8
[Synonyms]

LFS-1107
Hazard InformationBack Directory
[Uses]

LFS-1107 is a reversible CRM1 inhibitor (Kd: 12.5 pM). LFS-1107 can selectively eliminate extranodal natural killer/T cell lymphoma (ENKTL) cells and can be used for cancer research[1].
[in vivo]

LFS-1107 (10 mg/kg, Intraperitoneal injection,once a week) can ameliorate the symptoms of ENKTL in SNK6 cell xenograft mouse model[1].

Animal Model:SNK6 cell xenograft mouse model[1]
Dosage:10 mg/kg
Administration: Intraperitoneal injection (i.p.), once a week
Result:Extended mouse survival and Eliminated tumor cells.
[IC 50]

COX-2
[References]

[1] He Liu, et al. Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma eLife 12:e80625.
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1799330-91-8 149-91-7 106740-09-4 30652-11-0 154-23-4 490-46-0