| Identification | Back Directory | [Name]
LYS-006 | [CAS]
1799681-85-8 | [Synonyms]
LYS-006
LYS006 hcl
LTA4H-IN-1
βS-amino-5-[4-[(5-chloro-3-fluoro-2-pyridinyl)oxy]phenyl]-2H-tetrazole-2-butanoic acid
2H-Tetrazole-2-butanoic acid, β-amino-5-[4-[(5-chloro-3-fluoro-2-pyridinyl)oxy]phenyl]-, (βS)- | [Molecular Formula]
C16H14ClFN6O3 | [MDL Number]
MFCD32874145 | [MOL File]
1799681-85-8.mol | [Molecular Weight]
392.78 |
| Chemical Properties | Back Directory | [Boiling point ]
583.1±60.0 °C(Predicted) | [density ]
1.60±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 250 mg/mL (636.50 mM; Need ultrasonic) | [form ]
A solid | [pka]
3.54±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
LTA4H-IN-1 is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) extracted from patent WO2015092740A1, example 29, has an IC50 of 2 nM. LTA4H-IN-1 can be used for the research of inflammatory and autoimmune disorders[1]. | [in vivo]
LTA4H-IN-1 (0.3 mg/kg; a single p.o.) inhibits the -43% release of LTB4 compared with vehicle control in mice[1]. | [IC 50]
LTA4H hydrolase: 2 nM (IC50) | [References]
[1] Bollbuck B, et, al. Heteroaryl butanoic acid derivatives as leukotriene A4 hydrolase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. WO2015092740A1. |
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| Company Name: |
ChemeGen
|
| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|