| Identification | Back Directory | [Name]
Borussertib | [CAS]
1800070-77-2 | [Synonyms]
Borussertib
2-Propenamide, N-[3-[1-[[4-(5,6-dihydro-5-oxo-3-phenyl-1,6-naphthyridin-2-yl)phenyl]methyl]-4-piperidinyl]-2,3-dihydro-2-oxo-1H-benzimidazol-5-yl]- | [Molecular Formula]
C36H32N6O3 | [MDL Number]
MFCD32062807 | [MOL File]
1800070-77-2.mol | [Molecular Weight]
596.68 |
| Chemical Properties | Back Directory | [density ]
1.318±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 25 mg/mL (41.90 mM; Need ultrasonic) | [form ]
Solid | [pka]
10.74±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt[1]. | [storage]
Store at -20°C | [References]
[1] Niklas Uhlenbrock, et al. Structural and chemical insights into the covalentallosteric inhibition of the protein kinase Akt. Chem Sci., 2019, 10, 3573. |
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BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
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