| Identification | Back Directory | [Name]
L-Arginine, glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl- | [CAS]
1801959-12-5 | [Synonyms]
L-Arginine, glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl- | [Molecular Formula]
C35H55N11O9 | [MOL File]
1801959-12-5.mol | [Molecular Weight]
773.88 |
| Chemical Properties | Back Directory | [density ]
1.44±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.34±0.10(Predicted) | [color ]
White to off-white | [Sequence]
Gly-Val-Ser-Trp-Gly-Leu-Arg | [InChIKey]
CMNBQRXBBJQIOA-YIHYGEMESA-N | [SMILES]
C(O)(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)CN |
| Hazard Information | Back Directory | [Uses]
PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression[1]. | [in vivo]
PE 22-28 (i.p.; 3.0μg/kg) shows antidepressant property[1]. | Animal Model: | Na?ve male C57Bl/6J mice[1] | | Dosage: | 3.0μg/kg | | Administration: | Intraperitoneal | | Result: | Showed a significant reduction of the immobility time, reduced significantly the latency to eat the food pellet, induced neurogenesis and improved the action duration. |
| [References]
[1] Alaeddine Djillani, et al. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity. Front Pharmacol. 2017 Sep 12;8:643. DOI:10.3389/fphar.2017.00643 |
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