| Identification | Back Directory | [Name]
4-Quinazolinamine, N-(5-phenyl-1H-pyrazol-3-yl)-2-(4-pyridinyl)- | [CAS]
1802068-51-4 | [Synonyms]
N-(5-phenyl-1H-pyrazol-3-yl)-2-(pyridin-4-yl)quinazolin-4-amine
4-Quinazolinamine, N-(5-phenyl-1H-pyrazol-3-yl)-2-(4-pyridinyl)- | [Molecular Formula]
C22H16N6 | [MOL File]
1802068-51-4.mol | [Molecular Weight]
364.4 |
| Chemical Properties | Back Directory | [Boiling point ]
573.5±50.0 °C(predicted) | [density ]
1.342±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
13.17±0.10(predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Uses]
UNI418 is a dual inhibitor of PIKfyve and PIP5K1C with antiviral activity against SARS-CoV-2 (EC50=1.4 μM). UNI418 blocks ACE2-mediated SARS-CoV-2 viral endocytosis by inhibiting PIP5K1C (IC50=60.1 nM; Kd=61 nM). In addition, UNI418 inhibits the proteolytic activation of proteases regulated by PIKfyve (Kd=0.78 nM) to prevent SARS-CoV-2 from entering host cells[1]. | [References]
[1] Seo, et al. "A dual inhibitor of PIP5K1C and PIKfyve prevents SARS-CoV-2 entry into cells." Experimental & Molecular Medicine (2024): 1-14. DOI:10.1038/s12276-024-01283-2 |
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