| Identification | Back Directory | [Name]
2-Azetidinecarboxylic acid, 3-[(2-amino-4-pyridinyl)methyl]-1-[[[(1R)-1-cyclohexylethyl]amino]carbonyl]-4-oxo-, (2S,3R)- | [CAS]
1803270-60-1 | [Synonyms]
Frunexian
2-Azetidinecarboxylic acid, 3-[(2-amino-4-pyridinyl)methyl]-1-[[[(1R)-1-cyclohexylethyl]amino]carbonyl]-4-oxo-, (2S,3R)- | [Molecular Formula]
C19H26N4O4 | [MOL File]
1803270-60-1.mol | [Molecular Weight]
374.43 |
| Hazard Information | Back Directory | [Uses]
Frunexian (EP-7041) is a selective and potent inhibitor of coagulation factor XI/activated factor XI, targeting to factor XIa. Frunexian exhibits antithrombotic activity, with no bleeding liability in rat mesenteric arterial puncture model. Frunexian can be used in extracorporeal membrane oxygenation (ECMO) research[1]. | [References]
[1] Pollack CV Jr, et al. EP-7041, a Factor XIa Inhibitor as a Potential Antithrombotic Strategy in Extracorporeal Membrane Oxygenation: A Brief Report. Crit Care Explor. 2020 Sep 15;2(9):e0196. DOI:10.1097/CCE.0000000000000196 |
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