| Identification | More | [Name]
ETHYL 3,4-DIMETHOXYPHENYLACETATE | [CAS]
18066-68-7 | [Synonyms]
ETHYL 2-(3,4-DIMETHOXYPHENYL)ACETATE
ETHYL 3,4-DIMETHOXYPHENYLACETATE
HOMOVERATRIC ACID ETHYL ESTER
3,4-dimethoxy-benzeneaceticaciethylester
Acetic acid, (3,4-dimethoxyphenyl)-, ethyl ester
Benzeneacetic acid, 3,4-dimethoxy-, ethyl ester
Ethyl dimethoxyphenylacetate
3,4-Dimethoxyphenylacetic acid ethyl ester~Ethyl homoveratrate
ethyl homoveratrate
Ethyl 3,4-dimethoxyphenylacetate, 98+%
3,4-Dimethoxybenzeneacetic acid ethyl ester | [EINECS(EC#)]
241-974-9 | [Molecular Formula]
C12H16O4 | [MDL Number]
MFCD00017272 | [Molecular Weight]
224.25 | [MOL File]
18066-68-7.mol |
| Hazard Information | Back Directory | [Synthesis]
In a typical reaction, 3,4-dimethoxyphenylacetic acid (332 g, 0.6 mol), ethanol (1.5-2 mol), and AMA 2:3 were mixed in a provided reaction glass tube equipped with a screw cap and magnetic stirrer until a wet mixture was formed. The reaction mixture was placed in a microwave reactor (Anton Parr Monowave 300) and irradiated at 80°C for 8 min or 120°C for 20 min. Upon completion of the reaction, the mixture was cooled, diluted with dichloromethane (41 mL), filtered by gravity and the filtrate was washed with dichloromethane. Subsequently, the filtrate was washed with saturated sodium carbonate solution and water. The organic layer was separated, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give ethyl 3,4-dimethoxyphenylacetate. | [References]
[1] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 4, p. 1586 - 1605
[2] Journal of Organic Chemistry, 2003, vol. 68, # 3, p. 1165 - 1167
[3] Synthetic Communications, 2014, vol. 44, # 16, p. 2386 - 2392
[4] Journal of Organic Chemistry, 2010, vol. 75, # 19, p. 6549 - 6562
[5] Tetrahedron, 1997, vol. 53, # 30, p. 10555 - 10564 |
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