| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 5 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
ND-336 is a novel highly selective inhibitor of gelatinases (MMP-2 and MMP-9) and MMP-14. ND-336 accelerates diabetic wound healing by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound, thereby reversing the pathological condition. ND-336 holds considerable promise in healing of diabetic wounds. | [Uses]
ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-14, with Kis of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound[1][2]. | [in vivo]
ND-336 accelerates diabetic wound healing by decreasing inflammation and by enhancing angiogenesis and re-epithelialization of the wound, thus reversing the pathological condition[1].
ND-336 (0.05-0.01 mg; topical application; daily for 14 day) accelerates diabetic wound healing[1]. | Animal Model: | Female diabetic db/db mice[1] | | Dosage: | 0.05, 0.025, and 0.01 mg | | Administration: | Topical application; daily for 14 day | | Result: | Healed 1.2- to 1.6-fold faster than those treated with ND-322 than those treated with vehicle.
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| [IC 50]
MMP-2: 85 nM (Ki); MMP-9: 150 nM (Ki); MMP-14: 120 nM (Ki) | [storage]
Store at -20°C | [References]
[1] Gao M, et al. Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy. Proc Natl Acad Sci U S A. 2015;112(49):15226-15231. DOI:10.1073/pnas.1517847112
[2] Nguyen TT, et al. Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing. J Med Chem. 2018;61(19):8825-8837. DOI:10.1021/acs.jmedchem.8b01005 |
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| Company Name: |
Boao Pike
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| Tel: |
010-57798038 15652371397 |
| Website: |
www.biopike.cn |
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