1807453-83-3
1807453-83-3 结构式
物理化学性质
储存条件-20°C储存
溶解度DMF: 5 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml
形态结晶固体
颜色White to off-white
应用领域
用途一
ND-336 is a novel highly selective inhibitor of gelatinases (MMP-2 and MMP-9) and MMP-14. ND-336 accelerates diabetic wound healing by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound, thereby reversing the pathological condition. ND-336 holds considerable promise in healing of diabetic wounds.常见问题列表
概述
ND-336 是基质金属蛋白酶 (MMP)-2、MMP-9 和 MMP-14 的选择性抑制剂，Ki 分别为 85、150 和 120 nM。ND-336 通过降低炎症反应、促进创面血管生成和再上皮化，促进小鼠糖尿病创面愈合。