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1807537-40-1

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1807537-40-1 Structure

1807537-40-1 Structure
IdentificationBack Directory
[Name]

Hydroxy-PEG3-PFP ester
[CAS]

1807537-40-1
[Synonyms]

Hydroxy-PEG3-PFP ester
Hydroxy-PEG3-C2-PFP ester
[Molecular Formula]

C15H17F5O6
[MDL Number]

MFCD26793756
[MOL File]

1807537-40-1.mol
[Molecular Weight]

388.28
Chemical PropertiesBack Directory
[Boiling point ]

440.3±45.0 °C(Predicted)
[density ]

1.385±0.06 g/cm3(Predicted)
[pka]

14.36±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

Hydroxy-PEG3-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[Biological Activity]

Hydroxy-PEG3-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[IC 50]

PEGs
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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