| Identification | Back Directory | [Name]
PEG8-Tos | [CAS]
1028089-05-5 | [Synonyms]
PEG8-Tos
Tos-PEG7-OH
OH-PEG7-Tos
HO-(CH2CH2O)7-Tos
3,6,9,12,15,18-Hexaoxaeicosane-1,20-diol, 1-(4-methylbenzenesulfonate) | [Molecular Formula]
C21H36O10S | [MDL Number]
MFCD30536162 | [MOL File]
1028089-05-5.mol | [Molecular Weight]
480.57 |
| Hazard Information | Back Directory | [Description]
PEG8-Tos is a PEG linker containing a hydroxyl group with a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions. | [Uses]
Tos-PEG7-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6 |
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