| Identification | Back Directory | [Name]
3,4-Dibromo-Mal-PEG2-Boc-Amine | [CAS]
1807537-43-4 | [Synonyms]
3,4-Dibromo-Mal-PEG2-N-Boc
3,4-Dibromo-Mal-PEG2-NHBoc
3,4-Dibromo-Mal-PEG2-Boc-Amine
Carbamic acid, N-[2-[2-[2-(3,4-dibromo-2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C15H22Br2N2O6 | [MDL Number]
MFCD27635177 | [MOL File]
1807537-43-4.mol | [Molecular Weight]
486.15 |
| Chemical Properties | Back Directory | [Boiling point ]
513.0±50.0 °C(Predicted) | [density ]
1.609±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [form ]
Solid | [pka]
12.23±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
3,4-Dibromo-Mal-PEG2-Boc-Amine is a hydrophilic PEG species containing a dibromomaleimide group and a Boc-protected amine. The dibromomaleimide group allows for two points of attachement because both of the bromine atoms can be substituted. The Boc protecting group can be removed under acidic conditions and allows for the amine to further react with other species. The hydrophilic PEG linker increases the compound's water solubility properties in aqueous media. | [Uses]
3,4-Dibromo-Mal-PEG2-N-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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