| Identification | Back Directory | [Name]
O-[2-(Boc-aMino)ethyl]-O′-(2-MaleiMidoethyl)ethylene glycol | [CAS]
660843-21-0 | [Synonyms]
O-[2-(Boc-aMino)ethyl]-O′-(2-MaleiMidoethyl)ethylene glycol
O-[2-(Boc-amino)ethyl]-O'-(2-maleimidoethyl)ethylene glycol >=96.0% (HPLC)
tert-Butyl {2-{2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethyl}carbamate
Carbamic acid, N-[2-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C15H24N2O6 | [MDL Number]
MFCD12912379 | [MOL File]
660843-21-0.mol | [Molecular Weight]
328.36 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO, DCM | [InChI]
1S/C15H24N2O6/c1-15(2,3)23-14(20)16-6-8-21-10-11-22-9-7-17-12(18)4-5-13(17)19/h4-5H,6-11H2,1-3H3,(H,16,20) | [InChIKey]
ANPNLGYUZZQPEV-UHFFFAOYSA-N | [SMILES]
CC(C)(C)OC(=O)NCCOCCOCCN1C(=O)C=CC1=O |
| Hazard Information | Back Directory | [Description]
Mal-PEG2-NH-Boc is a PEG linker containing a maleimide group and a Boc protected amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | [Uses]
Mal-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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