| Identification | Back Directory | [Name]
3-Azetidinecarboxylic acid, 1-[[5-[1-[[4-chloro-3-(trifluoromethyl)phenyl]ethylamino]ethyl]-2-methylphenyl]methyl]- | [CAS]
1807873-14-8 | [Synonyms]
3-Azetidinecarboxylic acid, 1-[[5-[1-[[4-chloro-3-(trifluoromethyl)phenyl]ethylamino]ethyl]-2-methylphenyl]methyl]- | [Molecular Formula]
C23H26ClF3N2O2 | [MOL File]
1807873-14-8.mol | [Molecular Weight]
454.91 |
| Chemical Properties | Back Directory | [Boiling point ]
559.9±50.0 °C(predicted) | [density ]
1.311±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
2.70±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
KSI-6666 is an orally active, competitive antagonist for sphingosine 1-phosphate receptor 1 (S1PR1), with an IC50 of 6.4 nM. KSI-6666 exhibits anti-inflammatory efficacy in autoimmune encephalomyelitis model and T cell transfer colitis model[1]. | [IC 50]
S1PR1: 6.4 nM (IC50) | [References]
[1] Maruyama Y, et al. Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist[J]. bioRxiv, 2023: 2023.05. 08.539826. |
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