| Identification | Back Directory | [Name]
1808113-09-8 | [CAS]
1808113-09-8 | [Synonyms]
Corin
Benzenebutanamide, N-[4-[(1R,2S)-2-aminocyclopropyl]phenyl]-4-[[(2-aminophenyl)amino]carbonyl]-, rel- | [Molecular Formula]
C26H28N4O2 | [MDL Number]
MFCD31731097 | [MOL File]
1808113-09-8.mol | [Molecular Weight]
428.53 |
| Chemical Properties | Back Directory | [Boiling point ]
631.8±55.0 °C(Predicted) | [density ]
1.287±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (233.36 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
13.32±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1. | [References]
[1] Kalin JH, et al. Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors. Nat Commun. 2018 Jan 4;9(1):53. DOI:10.1038/s41467-017-02242-4 |
|
|