| Identification | Back Directory | [Name]
1-BOC-3-METHYL-PIPERIDIN-4-ONE | [CAS]
181269-69-2 | [Synonyms]
N-Boc-3-methyl-4-piperidone
1-Boc-3-Methyl-4-piperidone
1-BOC-3-METHYL-PIPERIDIN-4-ONE
N-BOC-3-Methyl-4-oxopiperidine
1-Boc-4-oxo-3-methyl-piperidine
N-TERT-BUTOXYCARBONYL-3-METHYL-4-PIPERIDONE
tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate
tert-Butyl 3-methyl-4-oxo-1-piperidinecarboxylate
(R,S)-tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate
3-Methyl-4-oxo-piperidine-1-carboxylicacidtert-butylester
1-Piperidinecarboxylicacid, 3-Methyl-4-oxo-, 1,1-diMethylethyl ester | [Molecular Formula]
C11H19NO3 | [MDL Number]
MFCD08460962 | [MOL File]
181269-69-2.mol | [Molecular Weight]
213.273 |
| Chemical Properties | Back Directory | [Melting point ]
45° | [Boiling point ]
298.8±33.0 °C(Predicted) | [density ]
1.060 | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
solid | [pka]
-1.54±0.40(Predicted) | [color ]
Off-white |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of N-Boc-3-methyl-piperidin-4-one (product 27B) from 1-benzyl-3-methyl-piperidin-4-one (compound 28, 15.0 g, 0.0738 mol) and di-tert-butyl dicarbonate (17.7 g, 0.0812 mol) was as follows: compound 28 and di-tert-butyl dicarbonate were dissolved in ethyl acetate (EtOAc , 400 mL). Palladium hydroxide catalyst (4 g) was added to the solution and the mixture was placed in a Paar oscillator and the reaction was oscillated at 40 psi hydrogen pressure for 24 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the diatomaceous earth was washed with ethyl acetate. The filtrates were combined and concentrated under reduced pressure to give the colorless oily product 27B (15.73 g, 0.0738 mol, 100% yield). Mass spectrometry analysis (ESI+, M-tBOC): m/z 114. | [References]
[1] Patent: US2005/182095, 2005, A1. Location in patent: Page/Page column 30
[2] Patent: WO2011/159852, 2011, A1. Location in patent: Page/Page column 11-12
[3] Patent: US2010/113465, 2010, A1. Location in patent: Page/Page column 34-35
[4] Patent: WO2018/5881, 2018, A1. Location in patent: Page/Page column 126
[5] Patent: US2010/204274, 2010, A1. Location in patent: Page/Page column 54-55 |
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