| Identification | Back Directory | [Name]
6-Isoquinolinecarboxamide, 1-[[(2S,3S,4S)-4-fluoro-3-methyl-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy- | [CAS]
1817628-40-2 | [Synonyms]
PF6426779
6-Isoquinolinecarboxamide, 1-[[(2S,3S,4S)-4-fluoro-3-methyl-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy- | [Molecular Formula]
C17H18FN3O4 | [MOL File]
1817628-40-2.mol | [Molecular Weight]
347.34 |
| Chemical Properties | Back Directory | [Boiling point ]
617.2±55.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.44±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PF-06426779 is a potent and selective inhibitor of interleukin 1 receptor associated kinase 4 (IRAK4), with an IC50 of 0.3 nM[1]. | [IC 50]
IRAK4: 0.3 nM (IC50) | [References]
[1] Lee KL, et, al. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J Med Chem. 2017 Jul 13; 60(13): 5521-5542. DOI:10.1021/acs.jmedchem.7b00231 |
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