| Identification | Back Directory | [Name]
Amino-PEG10-t-butyl ester | [CAS]
1818294-42-6 | [Synonyms]
Amino-PEG10-Boc
CAS_1818294-42-6
Amino-PEG10-COOtBu
NH2-PEG10-CH2COOtBu
H2N-PEG10-CH2CH2COOtBu
Amino-PEG10-t-butyl ester
Amino-PEG11-t-butyl ester
tert-Butyl 1-amino-3,6,9,12,15,18,21,24,27,30-decaoxatritriacontan-33-oate
4,7,10,13,16,19,22,25,28,31-Decaoxatritriacontanoic acid, 33-amino-, 1,1-dimethylethyl ester | [Molecular Formula]
C27H55NO12 | [MDL Number]
MFCD26127812 | [MOL File]
1818294-42-6.mol | [Molecular Weight]
585.73 |
| Chemical Properties | Back Directory | [Boiling point ]
606.9±50.0 °C(Predicted) | [density ]
1.074±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
8.74±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Amino-PEG10-t-butyl ester is a water soluble PEG reagent containing an amino group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Amino-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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