| Identification | Back Directory | [Name]
H2N-PEG2-tBu | [CAS]
756525-95-8 | [Synonyms]
H2N-PEG2-tBu
NH2-PEG2-C2-Boc
H2N-PEG2-CO-OtBu
Amino-PEG2-COOtBu
NH2-PEG2-CH2CH2COOtBu
H2N-PEG2-CH2CH2COOtBu
Amino-PEG2-t-butyl ester
Amino-PEG3-t-butyl ester
Amino-dPEG2-t-butyl ester
Amino-PEG2-tert-butyl ester
NH2-PEG2-CH2CH2-t-butylester
Amino-PEG2-acid -t-Butyl ester
tert-Butyl 3-(2-(2-aminoethoxy)
Amino-PEG2-acid tert-Butyl Ester
tert-Butyl 9-Amino-4,7-dioxanonanoate
AMINO-PEG2-PROPANOIC ACID T-BUTYL ESTER
9-Amino-4,7-dioxanonanoic Acid tert-Butyl Ester
tert-Butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate
α-Amino-ω-tert butyl propionate poly(ethylene glycol)
2-methyl-2-propanyl 3-[2-(2-aminoethoxy)ethoxy]propanoate
3-[2-(2-Aminoethoxy)ethoxy]propanoic Acid tert-Butyl Ester
1,1-Dimethylethyl Ester 3-[2-(2-Aminoethoxy)Ethoxy]Propanoic Acid
3-[2-(2-Aminoethoxy)ethoxy]propanoic acid 1,1-dimethylethyl ester
Propanoic acid, 3-[2-(2-aminoethoxy)ethoxy]-, 1,1-dimethylethyl ester
H2N-PEG2-CH2CH2COOtBu
tert-Butyl 9-AMino-4,7-dioxanonanoate (H2N-PEG2-tBu) tert-butyl 9-AMino-4,7-dioxanonanoate | [Molecular Formula]
C11H23NO4 | [MDL Number]
MFCD11041135 | [MOL File]
756525-95-8.mol | [Molecular Weight]
233.3 |
| Chemical Properties | Back Directory | [Boiling point ]
313.7±22.0 °C(Predicted) | [density ]
1.014±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
Liquid | [pka]
8.74±0.10(Predicted) | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C11H23NO4/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h4-9,12H2,1-3H3 | [InChIKey]
XIVHGTLMLORWEP-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)CCOCCOCCN |
| Hazard Information | Back Directory | [Description]
Amino-PEG2-t-butyl ester is a PEG linker containing an amino group with a t-butyl protected carboxyl group (Boc).The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
3-[2-(2-Aminoethoxy)Ethoxy]Propanoic Acid 1,1-Dimethylethyl Ester is used as reactant in the synthesis of self-localizing ligands that control spatial location of proteins in living cells. | [Synthesis]
General procedure for the synthesis of tert-butyl 9-amino-4,7-dioxanonanoate from the compound (CAS: 1629676-61-4): 5% Pd/C (JM US 2.14 g) was added to a solution of dibenzylamine 27 (35.0 g, 85 mmol) in methanol (420 mL), and the mixture was placed in an Atlantis reactor and subjected to a hydrogenation reaction at 40 °C and 15 psi hydrogen pressure for the hydrogenation reaction. After 2 h of reaction, the catalyst was removed by filtration and the filtrate was concentrated to yield 18.90 g (96% yield) of amine 7 as a turbid oil, which was used directly in the next step of the reaction without further purification.IR (ATR cells): 2977, 2868, 1727, 1456, 1393, 1367, 1254, 1157, 1113, 847, 755, 589, 564, 547, 536 cm^-1. ^1H NMR (400 MHz, CDCl3): δ = 1.30 (s, 9H), 2.36 (t, J = 6.43 Hz, 2H), 2.71 (t, J = 5.19 Hz, 2H), 3.36 (t, J = 5.19 Hz, 2H), 3.43-3.50 (m, 4H) , 3.57 (t, J = 6.64 Hz, 2H). ^13C NMR (100 MHz, CDCl3): δ = 28.18, 36.36, 41.92, 66.98, 70.32, 70.44, 73.58, 80.52, 170.92. HRMS (ESI): m/z [M + H]^+ Calculated value for C11H24NO4: 234.16998; measured value: 234.17009. | [IC 50]
PEGs; Alkyl/ether; Non-cleavable Linker | [References]
[1] Synthesis (Germany), 2014, vol. 46, # 10, p. 1399 - 1406
[2] Patent: WO2016/59622, 2016, A2. Location in patent: Page/Page column 104
[3] Patent: WO2017/46658, 2017, A1. Location in patent: Page/Page column 144
[4] Patent: WO2018/86139, 2018, A1. Location in patent: Page/Page column 152 |
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