| Identification | Back Directory | [Name]
2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile | [CAS]
1818885-54-9 | [Synonyms]
AR antagonist 1
2-chloro-4-[trans-3-amino-2,2,4,4-tetramethylcyclobutoxy]benzonitrile
Benzonitrile, 4-[(trans-3-amino-2,2,4,4-tetramethylcyclobutyl)oxy]-2-chloro- | [Molecular Formula]
C15H19ClN2O | [MDL Number]
MFCD30803693 | [MOL File]
1818885-54-9.mol | [Molecular Weight]
278.78 |
| Chemical Properties | Back Directory | [Boiling point ]
394.9±42.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [storage temp. ]
Store at 0-8 °C | [pka]
10.14±0.70(Predicted) | [Appearance]
white to off-white solid |
| Hazard Information | Back Directory | [Uses]
AR antagonist 1 (compound 29) is a potent androgen receptor (AR) antagonist and binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266 (HY-133020). | [IC 50]
VHL | [References]
[1] Han X, et al. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands. J Med Chem. 2019 Dec 26;62(24):11218-11231. DOI:10.1021/acs.jmedchem.9b01393 |
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