| Identification | Back Directory | [Name]
Azido-PEG1-CH2CO2tBu | [CAS]
1820717-35-8 | [Synonyms]
CAS_1820717-35-8
Azido-PEG1-C1-Boc
Azido-PEG1-CH2CO2tBu
Azido-PEG1-CH2COOtBu
Azido-PEG1-t-butyl acetate
Azido-PEG1-CH2COOH t-Bu Ester
Azido-PEG1-CH2CO2-t-butyl ester
tert-Butyl 2-(2-azidoethoxy)acetate
Azido-PEG1-CH2CO2-t-Bu,Azido-PEG1-CH2CO2-t-butyl Ester | [Molecular Formula]
C8H15N3O3 | [MDL Number]
MFCD27635154 | [MOL File]
1820717-35-8.mol | [Molecular Weight]
201.223 |
| Hazard Information | Back Directory | [Description]
Azido-PEG1-CH2CO2-t-Bu is a azide (N3) containing PEG linker.The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Azido-PEG1-C1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-C1-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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| Company Name: |
Henan Alfachem Co.,Ltd.
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0371-55051623 18137891487 |
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www.chemicalbook.com/supplier/14555231/ |
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