| Identification | Back Directory | [Name]
Bromo-PEG1-CH2CO2tBu | [CAS]
157759-50-7 | [Synonyms]
CAS_157759-50-7
Bromo-PEG1-CH2-Boc
Bromo-PEG1-CH2CO2tBu
Bromo-PEG1-CH2COOtBu
t-butyl acetate-PEG1-bromide
tert-Butyl 2-(2-bromoethoxy)acetate
Acetic acid, 2-(2-bromoethoxy)-, 1,1-dimethylethyl ester | [Molecular Formula]
C8H15BrO3 | [MDL Number]
MFCD28122952 | [MOL File]
157759-50-7.mol | [Molecular Weight]
239.11 |
| Chemical Properties | Back Directory | [Boiling point ]
268.1±15.0 °C(Predicted) | [density ]
1.301±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DCM | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Bromo-PEG1-CH2CO2tBu is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Bromo-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
| Company Name: |
T&W GROUP
|
| Tel: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
|