| Identification | Back Directory | [Name]
IRAK4-IN-1 | [CAS]
1820787-94-7 | [Synonyms]
IRAK4-IN-1
IRAK4-IN-1, >98%
IRAK4 inhibitor 1
6-Quinazolinecarbonitrile, 4-[[trans-4-(4-morpholinyl)cyclohexyl]amino]- | [Molecular Formula]
C19H23N5O | [MDL Number]
MFCD31620830 | [MOL File]
1820787-94-7.mol | [Molecular Weight]
337.42 |
| Chemical Properties | Back Directory | [Boiling point ]
548.9±50.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 14.29 mg/mL (42.35 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
7.81±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM. | [in vivo]
Oral pharmacokinetic studies of IRAK4-IN-1 (Compound 23) show it to have high bioavailability of 73% and low plasma clearance
(Clp=22 mL/min/kg) leading to a reasonable half-life of 1.3 h[1]. | [storage]
Store at -20°C | [References]
[1] Smith GF, et al. Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2721-2726. DOI:10.1016/j.bmcl.2017.04.050 |
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