| Identification | Back Directory | [Name]
1-Piperazineacetamide, N-[trans-4-(acetylamino)cyclohexyl]-4-[5-(4-methylphenyl)-1,2,4-triazin-3-yl]- | [CAS]
1820940-17-7 | [Synonyms]
lorundrostat
Lorundrostat/MT-4129
N-[trans-4-(Acetylamino)cyclohexyl]-4-[5-(4-methylphenyl)-1,2,4-triazin-3-yl]-1-piperazineacetamide
1-Piperazineacetamide, N-[trans-4-(acetylamino)cyclohexyl]-4-[5-(4-methylphenyl)-1,2,4-triazin-3-yl]- | [Molecular Formula]
C24H33N7O2 | [MOL File]
1820940-17-7.mol | [Molecular Weight]
451.56 |
| Chemical Properties | Back Directory | [density ]
1.26±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
14.86±0.40(Predicted) | [color ]
Light yellow to yellow | [InChIKey]
YHGVDZULVMINCJ-MEMLXQNLSA-N | [SMILES]
N1(CC(N[C@@H]2CC[C@@H](NC(C)=O)CC2)=O)CCN(C2=NC(C3=CC=C(C)C=C3)=CN=N2)CC1 |
| Hazard Information | Back Directory | [Uses]
Lorundrostat (MT-4129) is an orally active aldosterone synthase inhibitor. Lorundrostat can be used in studies of high blood pressure[1][2]. | [References]
[1] International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022.
[2] Laffin LJ, et al. Aldosterone Synthase Inhibition With Lorundrostat for Uncontrolled Hypertension: The Target-HTN Randomized Clinical Trial. JAMA. 2023 Sep 26;330(12):1140-1150 DOI:10.1001/jama.2023.16029
[3] Hideki K, et al., Novel disubstituted 1,2,4-triazine compounds. WO2015163427. |
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Wuhan Topule Gold
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