| Identification | Back Directory | [Name]
Methyltetrazine-Sulfo-NHS Ester | [CAS]
1821017-46-2 | [Synonyms]
Methyltetrazine-Sulfo-NHS Ester
Methyltetrazine-Sulfo-NHS ester sodium | [Molecular Formula]
C15H12N5O7S.Na | [MDL Number]
MFCD29052195 | [MOL File]
1821017-46-2.mol | [Molecular Weight]
431.35 |
| Hazard Information | Back Directory | [Uses]
Methyltetrazine-Sulfo-NHS ester (sodium) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [Biological Activity]
Methyltetrazine-Sulfo-NHS ester (sodium) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
Alkyl/ether | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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